Global burden of chronic kidney disease due to hypertension (1990–2021): a systematic analysis of epidemiological trends, risk factors, and projections to 2036 from the GBD 2021 study

作者：Yujun He, Weiwei Tang, Jianying Chen, Jie Tang, Yu Zheng, Xinyuan Wang, Xinyuan Wang, Bowen Xing, Xiaojun Li, Yi Xu, Xiaoyi Wang, Xiaoyi Wang · 发表于：BMC Nephrology · 年份：2025 · DOI：10.1186/s12882-025-04386-8 · 被引用次数：11 · 研究领域：Chronic Kidney Disease and Diabetes、Blood Pressure and Hypertension Studies、Dialysis and Renal Disease Management

BACKGROUND: Hypertension is a major risk factor for chronic kidney disease (CKD), and the global burden of CKD due to hypertension is rising with population aging. Previous GBD-related studies on CKD have limitations, and the updated global burden of disease (GBD) 2021 database can provide a more comprehensive understanding. OBJECTIVE: This study aims to analyze the global, regional, and national burden of CKD due to hypertension from 1990 to 2021, identify risk factors, and project trends until 2036. METHOD: Data from the GBD 2021 study for 204 countries and territories were used. Prevalence, incidence, deaths, and disability-adjusted life years (DALYs) of CKD due to hypertension were analyzed. Decomposition analysis, frontier analysis, and predictive analysis were performed. The impact of level 3 risk factors was also assessed. RESULTS: In 2021, the global prevalence of CKD attributed to hypertension exceeded 24 million cases, with an age-standardized prevalence rate of 291.19 per 100,000. The incidence of such CKD cases surpassed 1.28 million, corresponding to an age-standardized incidence rate of 14.97 per 100,000. Mortality from CKD due to hypertension claimed over 454,000 lives, translating to an age-standardized mortality rate of 5.54 per 100,000. Additionally, the disease inflicted more than 10.85 million DALYs, which equates to an age-standardized DALYs rate of approximately 128.41 per 100,000. There were gender and age differences in the disease burden. Decompositio...