Organoid-based modeling and regenerative strategies for salivary gland dysfunction

作者：Hee-Jeong Park, Jaejin Cho, Su‐Jeong Oh, Hyung Sik Kim · 发表于：Korean Journal of Physiology and Pharmacology · 年份：2025 · DOI：10.4196/kjpp.25.149 · 被引用次数：4 · 研究领域：Salivary Gland Disorders and Functions

models for studying SG homeostasis and pathology. SGOs serve as physiologically relevant three-dimensional models, enabling the study of tissue renewal, stem cell-niche interactions, and responses to genetic mutations, drugs, or injury. Additionally, advances in regenerative medicine, including stem cell-or organoid-based therapies integrated with bioengineering approaches, have the potential to develop future treatments. In this review, we summarize the latest progress in SGO development, explore its potential for modeling diseases and injuries, and discuss emerging regenerative strategies for restoring SG function. By deepening our understanding of SG physiology and diseases, these studies pave the way for therapeutic or regenerative approaches that have the potential to provide lasting relief for patients with xerostomia.