UDFF and Auto pSWE accurately assess liver steatosis and fibrosis risk in obese patients with MASLD

作者：Nina Dominik, Larissa Nixdorf, Michael Schwarz, Benedikt Hofer, Lukas Hartl, Lorenz Balcar, Georg Semmler, Benedikt Simbrunner, L. Fritz, Laurenz Hauptmann, Mathias Jachs, Julia Jedamzik, Behrang Mozayani, Lisa Gensthaler, Daniel Moritz Felsenreich, Mattias Mandorfer, Felix B. Langer, Michael Trauner, Thomas Reiberger, Gerhard Prager, David Bauer · 发表于：Ultraschall in der Medizin - European Journal of Ultrasound · 年份：2025 · DOI：10.1055/a-2592-1431 · 被引用次数：4 · 研究领域：Liver Disease Diagnosis and Treatment、Diet, Metabolism, and Disease、Liver Disease and Transplantation

Metabolic dysfunction-associated steatotic liver disease (MASLD) can progress to fibrosis and cirrhosis. Fibrosis and steatosis assessment with vibration-controlled transient elastography (VCTE) and controlled attenuation parameter (CAP) requires a dedicated device and time to obtain ≥10 reliable measurements. Auto pSWE allows for the simultaneous collection of 15 ARFI-based liver stiffness measurements (LSM) and UDFF-based steatosis assessment in a single acquisition.This prospective study included patients undergoing liver biopsy, primarily during bariatric surgery, between 11/2021-12/2023. Paired LSM by Auto pSWE/VCTE and steatosis assessments by UDFF/CAP were performed within a median of 1 day before or after biopsy.134 patients (65% women, mean age: 42.6±13.3 years) with a high prevalence of obesity (mean BMI: 42.7±10.4; MASLD etiology: 88%) were included. Liver biopsy showed significant fibrosis (≥F2) in 27% of patients and moderate steatosis (≥S2) in 51%. A single 1×15 Auto pSWE acquisition and one UDFF measurement were as accurate as the median of 5 measurements. Auto pSWE (AUC: ≥F2=0.58, ≥F3=0.96, F4=0.97) and VCTE (AUC: ≥F2=0.60, ≥F3=0.92, F4=0.93) demonstrated high accuracy for advanced fibrosis stages. UDFF (AUC: ≥S1=0.79, ≥S2=0.78, S3=0.67) and CAP showed similar diagnostic accuracy.Auto pSWE and UDFF provide accurate, noninvasive tests for advanced liver fibrosis and steatosis in MASLD, even in severely obese patients. Notably, Auto pSWE captures 15 LSM with UDF...