Lewis Acid-Catalyzed Cyclization of o-Hydroxyphenyl Propargylamines with Sodium Sulfinates: Syntheses of 3-Sulfonylbenzofurans

作者：Yuqing Wang, Lijia Chen, Yi Liu, Ruilin Yang, Jun Ying, Xiang‐Zhi Zhang, Jin‐Bao Peng · 发表于：The Journal of Organic Chemistry · 年份：2025 · DOI：10.1021/acs.joc.5c01123 · 被引用次数：4 · 研究领域：Sulfur-Based Synthesis Techniques、Synthesis of Indole Derivatives、Catalytic C–H Functionalization Methods

A Lewis acid-catalyzed cyclization for the synthesis of 3-sulfonylated benzofurans using o -hydroxyphenyl propargylamines and sodium sulfinate compounds has been developed. This reaction proceeds through: (i) acid-mediated in situ generation of o -AQMs, (ii) sulfite ion-initiated sulfa-Michael addition, followed by (iii) Lewis acid-promoted annulation, enabling efficient construction of 3-sulfonylbenzofurans in generally good to excellent yields.