Novel antimicrobial and bioactive resin-based clear aligner attachment orthodontic materials

作者：Heba Alqarni, Ibrahim Ba-Armah, Nader Almutairi, Mohammad Alenizy, Dwayne Arola, Thomas W. Oates, Jirun Sun, Michael D. Weir, Hockin H.K. Xu · 发表于：Frontiers in Oral Health · 年份：2025 · DOI：10.3389/froh.2025.1630019 · 被引用次数：5 · 研究领域：Orthodontics and Dentofacial Orthopedics、Dental materials and restorations、Dental Implant Techniques and Outcomes

Introduction Clear aligner orthodontic treatment provides a hygienic and esthetic alternative to fixed appliances; however, the required resin attachments can promote plaque accumulation and increase the risk of white-spot lesions in enamel. This study aimed to develop a novel resin-based antibacterial and bioactive orthodontic clear aligner attachment and evaluate its mechanical and antibacterial properties. Methods A resin matrix composed of urethane dimethacrylate (UDMA) and triethylene glycol divinylbenzyl ether (TEG-DVBE) was modified with 3% dimethylaminododecyl methacrylate (DMADDM) for antibacterial effects and nano-amorphous calcium phosphate (NACP) to support remineralization. Transbond™ LV and Vitremer™ were selected as commercial controls. Mechanical properties (flexural strength, elastic modulus, microhardness, and shear bond strength), degree of conversion, and antibacterial performance against Streptococcus mutans (S. mutans) biofilms were assessed through colony forming units (CFU), biofilm metabolic activity (MTT), and lactic acid production. Results All experimental groups showed flexural strength of 100.6–109.2 MPa, exceeding the ISO standard for resin-based materials. Degree of conversion in experimental groups ranged from (53.4 ± 2.3 to 69 ± 0.9) %, significantly exceeding (47.5 ± 0.1) % for Transbond control ( p < 0.05). Hardness was (0.21 ± 0.03) GPa for Transbond control, statistically comparable to (0.20 ± 0.02) GPa for the 20% NACP + 45% glass...