ThDP-dependent enzyme catalyzed oxidation of aldehydes

作者：Xiaoyang Chen, Meiting Zhou, Xinyu Duan, Yuting Zhang, Xiaohe Chu, Jian Xu · 发表于：Chemical Science · 年份：2025 · DOI：10.1039/d5sc03250d · 被引用次数：6 · 研究领域：Biochemical Acid Research Studies、Alcoholism and Thiamine Deficiency、Metabolism and Genetic Disorders

) as the oxidant. The reaction exhibits high efficiency (yield up to 99% and turnover number up to 2000) and achieves effective stereoselective control for dynamic kinetic resolutions (e.e. up to 99%). This study uncovers a previously undiscovered capability of ThDP-dependent enzymes, thus broadening the functional repertoire of this enzyme class.