Maternal oxidative stress throughout pregnancy and early childhood neurodevelopment at different stages: insights from a prospective cohort study

作者：Sen He, Jingyu Wang, Shuting Cao, Aizhen Wang, Yuyan Wang, Pei Li, Xiuli Cao, Rongrong Cheng, Ruixin Chen, Yin Wang, Fei Yang, Yuehao Fu, Yang Peng, Han Li, Wei Xia, Zhiqiang Zhu, Hongxiu Liu, Shunqing Xu · 发表于：BMC Medicine · 年份：2025 · DOI：10.1186/s12916-025-04297-3 · 被引用次数：12 · 研究领域：Tryptophan and brain disorders、Maternal Mental Health During Pregnancy and Postpartum、Folate and B Vitamins Research

BACKGROUND: Maternal oxidative stress during pregnancy plays a role as a hazardous factor of offspring neurodevelopment in animal models. However, epidemiological evidence remains limited. In this prospective cohort, we aimed to investigate the associations between maternal oxidative stress biomarkers (OSBs) across pregnancy and neurodevelopmental outcomes in different stages across early childhood. METHODS: This was a prospective cohort study conducted in 1791 mother-child pairs from Wuhan, China. Three OSBs, including DNA oxidative damage marker (8-hydroxy-2'-deoxyguanosine, 8-OHdG), RNA oxidative damage marker (8-hydroxyguanosine, 8-OHG) and lipid oxidative damage marker (4-hydroxy nonenal mercapturic acid, HNE-MA), were measured in repeatedly collected urine samples in three trimesters across pregnancy. We followed children at age 2, age 3, and age 6 years. At age 2 years, the Bayley Scales of Infant Development of China Revision (BSID-CR) was employed to assess children's mental and psychomotor development. Brain-derived neurotrophic factor (BDNF) levels were measured in children's plasma at age 3 years. The Wechsler Preschool and Primary Scale-Fourth Edition (WPPSI-IV) was used to assess children's intelligence quotients at ages 6 years. Generalized estimating equation models were applied to estimate the associations between OSBs and neurodevelopmental outcomes. RESULTS: Higher maternal HNE-MA levels in late pregnancy were associated with lower mental development index ...