Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitis

作者：Yi Chen, Zhimin Wu, Lucy Yue Lau, Boyang Li, Yipeng Pan, Alice Yang, Yuanyuan Zhang, Chao Shu, Yifei Ma, Hongyi Zhang, Wenjia Guo · 发表于：Food and Agricultural Immunology · 年份：2025 · DOI：10.1080/09540105.2025.2529306 · 被引用次数：5 · 研究领域：Dermatology and Skin Diseases、Urticaria and Related Conditions、Hair Growth and Disorders

Background: The causal relationship between Omega-3 fatty acids and nummular dermatitis remains unclear.Methods: We performed a two-sample Mendelian randomization analysis using six independent SNPs associated with circulating Omega-3 levels. Summary statistics for nummular dermatitis were obtained from the FinnGen consortium. The inverse variance weighted method was the primary analysis, complemented by MR-Egger, weighted median, and mode-based approaches. Sensitivity analyses assessed pleiotropy and heterogeneity.Results: Higher genetically predicted Omega-3 levels were significantly associated with a reduced risk of nummular dermatitis (β = −0.25, 95% CI: – 0.45 to – 0.06, P = 0.0111). The association was consistent across multiple MR methods, with no evidence of horizontal pleiotropy or significant heterogeneity.Conclusion: This study provides the first genetic evidence supporting a protective causal effect of Omega-3 fatty acids against nummular dermatitis, highlighting the potential of nutritional interventions for inflammatory skin diseases.