Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

作者：Xue-Ru Fan, Ye He, Yin-Shan Wang, Lei Li, Chris Adamson, Sophie Adler, Aaron Alexander‐Bloch, Evdokia Anagnostou, Kevin Anderson, Ariosky Areces-González, Duncan E. Astle, Bonnie Auyeung, Muhammad Ayub, Jong Bin Bae, Gareth Ball, Simon Baron‐Cohen, Richard Beare, Saashi A. Bedford, Vivek Benegal, Richard A. I. Bethlehem, Frauke Beyer, John Blangero, Manuel Blesa, James P. Boardman, Matthew Borzage, Jorge Bosch‐Bayard, Niall Bourke, Edward T. Bullmore, Vince D. Calhoun, M. Mallar Chakravarty, Christina Chen, Casey Chertavian, Gaël Chételat, Yap Seng Chong, Aiden Corvin, Manuela Costantino, Eric Courchesne, Fabrice Crivello, Vanessa Cropley, Jennifer Crosbie, Nicolás Crossley, Marion Delarue, Richard Delorme, Sylvane Desrivières, Gabriel A. Devenyi, Maria A. Di Biase, Raymond J. Dolan, Kirsten A. Donald, Gary Donohoe, Lena Dorfschmidt, Katharine Dunlop, A. David Edwards, Jed T. Elison, Cameron T. Ellis, Jeremy A. Elman, Lisa T. Eyler, Damien A. Fair, Paul C. Fletcher, Peter Fonagy, Carol E. Franz, Lídice Galán‐Garcia, Ali Gholipour, Jay N. Giedd, John H. Gilmore, David C. Glahn, Ian M. Goodyer, P. Ellen Grant, Nynke A. Groenewold, Shreya Gudapati, Faith M. Gunning, Raquel E. Gur, Ruben C Gur, Christopher Hammill, Oskar Hansson, Trey Hedden, Andreas Heinz, Richard N. Henson, Katja Heuer, Jacqueline Hoare, Bharath Holla, Avram J. Holmes, Hao Huang, Jonathan Ipser, Clifford R. Jack, Andrea Parolin Jackowski, Tianye Jia, David T. Jones, Peter B. Jones, René S. Kahn, Hasse Karlsson, Linnéa Karlsson, Ryuta Kawashima, Elizabeth A. Kelley, Silke Kern, Ki-Woong Kim, Manfred G. Kitzbichler, William S. Kremen, François Lalonde, Brigitte Landeau, Jason P. Lerch, John D. Lewis, Jiao Li, Wei Liao, Conor Liston, Michael Lombardo, Jinglei Lv, Travis T. Mallard, Machteld Marcelis, Samuel R. Mathias, Bernard Mazoyer, Philip McGuire, Michael J. Meaney, Andrea Mechelli, Bratislav Misic, Sarah E. Morgan, David Mothersill, Cynthia M. Ortinau, Rik Ossenkoppele, Minhui Ouyang, Lena Palaniyappan, Léo Paly, Pedro Mário Pan, Christos Pantelis, Min Tae M Park, Tomaš Paus, Zdenka Pausová, Deirel Paz-Linares, Alexa Pichet Binette, Karen Pierce, Xing Qian, Anqi Qiu, Armin Raznahan, Timothy Rittman, Amanda Rodrigue, Caitlin K. Rollins, Rafael Romero-Garcia, Lisa Ronan, Monica D. Rosenberg, David H. Rowitch, Giovanni Abrahão Salum, Theodore D. Satterthwaite, H. Lina Schaare, Jenna Schabdach, Russell Schachar, Michael Schöll, Aaron P. Schultz, Jakob Seidlitz, David Sharp, Russell T. Shinohara, Ingmar Skoog, Christopher D. Smyser, Reisa A. Sperling, Dan J. Stein, Aleks Stolicyn, John Suckling, Gemma Sullivan, Benjamin Thyreau, Roberto Toro, Nicolas Traut, Kamen A. Tsvetanov, Nicholas B. Turk-Browne, Jetro J. Tuulari, Christophe Tzourio, Étienne Vachon‐Presseau, Mitchell Valdés-Sosa, Pedro A. Valdés‐Sosa, Sofie L. Valk, Thérèse van Amelsvoort, Simon Vandekar, Lana Vasung, Petra E. Vértes, Lindsay W. Victoria, Sylvia Villeneuve, Arno Villringer, Jacob W. Vogel, Konrad Wagstyl, Yin-Shan Wang, Simon K. Warfield, Varun Warrier, Eric Westman, Margaret L. Westwater, Heather C. Whalley, Simon R. White, A. Veronica Witte, Ning Yang, B. T. Thomas Yeo, Hyuk Jin Yun, Andrew Zalesky, Heather J. Zar, Anna Zettergren, Juan Zhou, Hisham Ziauddeen, Dabriel Zimmerman, André Zugman, Xi‐Nian Zuo, Miaoshui Bai, Jinhua Cai, Kelong Cai, Doudou Cao, Xuan Cao, Aiguo Chen, Huafu Chen, Jie Chen, Xujun Duan, Xue-Ru Fan, Peng Gao, Wenjing Gao, DongZhi He, Feiyong Jia, Haoxiang Jiang, Xi Jiang, Jing Jin, Lei Li, Shijun Li, Tingyu Li, Xiuhong Li, Li‐Zi Lin, Yingqiang Liu, Zhimei Liu, Fanchao Meng, Ni Li, Ning Pan, Qi Qi, Bin Qin, Xiaolong Shan, Xiao‐Jing Shou, Jia Wang, Longlun Wang, Miaoyan Wang, Wei Wang, Xin Wang, Lijie Wu, Dandan Xu, Xu-Cheng Yin, Yang Xue, Ting Yang, Xuntao Yin, Rong Zhang, Yun Zhang, Xi‐Nian Zuo, Xujun Duan, Xi‐Nian Zuo · 发表于：Communications Biology · 年份：2025 · DOI：10.1038/s42003-025-08573-z · 被引用次数：3 · 研究领域：Autism Spectrum Disorder Research、Functional Brain Connectivity Studies、Genetics and Neurodevelopmental Disorders

We explore neurodevelopmental heterogeneity in Autism Spectrum Disorder (ASD) through normative modeling of cross-cultural cohorts. By leveraging large-scale datasets from Autism Brain Imaging Data Exchange (ABIDE) and China Autism Brain Imaging Consortium (CABIC), our model identifies two ASD subgroups with distinct brain morphological abnormalities: subgroup “L” is characterized by generally smaller brain region volumes and higher rates of abnormality, while subgroup “H” exhibits larger volumes with less pronounced deviations in specific areas. Key areas, such as the isthmus cingulate and transverse temporal gyrus, were identified as critical for subgroup differentiation and ASD trait correlations. In subgroup H, the regional volume of the isthmus cingulate cortex showed a direct correlation with individuals’ autistic mannerisms, potentially corresponding to its slower post-peak volumetric declines during development. These findings offer insights into the biological mechanisms underlying ASD and support the advancement of subgroup-driven precision clinical practices. Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.