Outcomes for FOLFIRI plus bevacizumab or cetuximab in patients treated with oxaliplatin-based adjuvant therapy: A combined analysis of FIRE-3 and CALGB/SWOG 80405 (Alliance)

作者：Francesca Battaglin, Bert H. O’Neil, Sebastian Stintzing, Fang‐Shu Ou, Tyler Zemla, Donna Niedzwiecki, Federico Innocenti, Howard S. Höchster, Ludwig Fischer von Weikersthal, Thomas Decker, Alexander Kiani, Ursula Vehling‐Kaiser, Tobias Heintges, Christian Lerchenmüller, Lena Weiss, Kathrin Heinrich, Richard M. Goldberg, Robert J. Mayer, Richard L. Schilsky, Charles D. Blanke, Alan P. Venook, Heinz‐Josef Lenz, Volker Heinemann · 发表于：European Journal of Cancer · 年份：2025 · DOI：10.1016/j.ejca.2025.115694 · 被引用次数：1 · 研究领域：Colorectal Cancer Treatments and Studies、Colorectal Cancer Surgical Treatments、Colorectal and Anal Carcinomas

BACKGROUND: Metastatic recurrence of colorectal cancer (mCRC) after adjuvant therapy may differ biologically from recurrence in untreated mCRC. We examined first-line treatment outcomes of patients within the phase III CALGB/SWOG 80405 (CALGB 80405) and FIRE-3 trials according to previous exposure to oxaliplatin-based adjuvant treatment. METHODS: Patients from CALGB 80405 primary analysis (N = 1131) and FIRE-3 intent-to-treat population (N = 592) treated with FOLFIRI who previously received either oxaliplatin-based adjuvant therapy or no adjuvant therapy were identified. Progression-free survival (PFS) and overall survival (OS) were estimated by the Kaplan-Meier method and compared using the log-rank test. Adjusted Cox regression models were used to compare outcomes according to biologic agent and prior adjuvant treatment. RESULTS: A total of 800 patients were included in the analysis. There were no significant differences in OS and PFS based on adjuvant treatment. Among patients who received adjuvant oxaliplatin-based chemotherapy (N = 123), median PFS was 11.5 months for FOLFIRI-bevacizumab (bev) and 10.1 months for FOLFIRI-cetuximab (cet) (adjusted HR [95 %CI] = 0.81 [0.56, 1.18], p = 0.27). Median OS in the same group was 41.0 months for bev- vs 28.5 months for cet-treated patients (adjusted HR 95 %CI] = 0.78 [0.51, 1.20], p = 0.26). No significant interaction between treatment arm and prior adjuvant treatment was identified. CONCLUSIONS: No statistically significant diff...