Lanosdracaenin A and (±)-Neodracaflavonoids A, Triterpenoid and Flavonoids with Anti-Inflammatory Activities from Dracaena cochinchinensis

作者：Wei Li, Yanfu Wang, Jinchang Liu, Yinglin Zheng, Xiongyi Zhang, Jing‐Xin Liu, Junping Pei, Xiaoyun Lu, Weihuan Huang, Ren‐Wang Jiang, Hai‐Yan Tian · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c02756 · 被引用次数：6 · 研究领域：Phytochemical Studies and Bioactivities、Natural product bioactivities and synthesis、Biological Activity of Diterpenoids and Biflavonoids

Lanosdracaenin A ( 1 ), an unprecedented triterpenoid, featuring a cleaved C ring and a lactonized D ring, and (±)-neodracaflavonoids A [(±)- 2 ], a pair of rearranged flavonoids, were isolated from the resinous wood of Dracaena cochinchinensi . The absolute configurations of these compounds were determined by NMR spectroscopy, ECD calculations, and X-ray crystallography. All compounds exhibited significant anti-inflammatory effects in zebrafish model and LPS-stimulated RAW264.7 cells and suppressed the expression of the inflammation related genes IL-1β and IL-6 .