US expert Delphi consensus on the prevention and management of stomatitis in patients treated with datopotamab deruxtecan

作者：Hope S. Rugo, Aditya Bardia, Debora Santos Bruno, Vinicius Ernani, Erika Paige Hamilton, Rebecca Suk Heist, Komal Jhaveri, Benjamin A. Levy, Aaron Elliott Lisberg, Joyce O’Shaughnessy, Jacob M. Sands, Alexander I. Spira, Sara M. Tolaney, Nathaniel Simon Treister, Cecile Matthews, Melissa Martinez Johnson · 发表于：Supportive Care in Cancer · 年份：2025 · DOI：10.1007/s00520-025-09805-y · 被引用次数：6 · 研究领域：Oral Health Pathology and Treatment、Colorectal Cancer Treatments and Studies、Lung Cancer Treatments and Mutations

BACKGROUND: Datopotamab deruxtecan (Dato-DXd) is an investigational antibody-drug conjugate that has shown promising results in phase III clinical trials of lung and breast cancers. Stomatitis is a common adverse event associated with Dato-DXd in these trials, and there are currently no formalized guidelines for its prevention and management. An expert consensus was needed to establish these guidelines. METHODS: Fifteen experts participated in a modified three-round Delphi to achieve consensus on the prevention and management of Dato-DXd-related stomatitis in lung and breast cancer patients. Fourteen experts had managed Dato-DXd-induced stomatitis and served as investigators in the TROPION-Lung01, TROPION-Lung05, and TROPION-Breast01 phase III clinical trials. The first two rounds consisted of anonymized surveys with a mixture of open- and closed-ended questions, and the third round consisted of a consensus group meeting and 1:1 follow-up meetings. FINDINGS: Experts recognized stomatitis as an important adverse event associated with several anticancer treatments and its impact on patients' quality of life. Lung and breast cancer specialists noted similar manifestations of stomatitis with Dato-DXd, with breast cancer experts referencing similarities to everolimus-induced conditions and lung cancer experts reporting ulcerative lesions. There was consensus on the need for standardized guidelines to improve outcomes and reduce treatment disruptions. Agreed preventive measures emp...