PTEN-mediated senescence of lung epithelial cells drives ventilator-induced pulmonary fibrosis

作者：Mengyu Li, Yu Wang, Zhiqiang Hu, Shiqian Huang, Pu Chen, Lin Chen, Jing Wu, Zhouyang Wu, Shanglong Yao, Yiyi Yang · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.117523 · 被引用次数：3 · 研究领域：Neonatal Respiratory Health Research、Respiratory Support and Mechanisms、Hydrogen's biological and therapeutic effects

RATIONALE: Our study demonstrates that PTEN plays a pivotal role in MV-PF, by mediating pulmonary epithelial cell senescence. Future studies may focus on developing strategies to modulate PTEN activity and cell senescence to prevent or treat this devastating disease.