An unrecognized mechanism of self-protection in degenerating neurons mediated by astrocytic YAP through Wnts/β-catenin/EAAT2 signaling in C9orf72-poly-GA mice

作者：Dongmei Li, Yan Wei, Rui Yang, Xuan Luo, Yanzhu Liu, Weiqiao Zhao, Hui Yang, Yumin Wu, Ying Wang, Zhihui Huang · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.113599 · 被引用次数：3 · 研究领域：Amyotrophic Lateral Sclerosis Research、Hippo pathway signaling and YAP/TAZ、Pluripotent Stem Cells Research

These results identify an unrecognized mechanism of self-protection in degenerating neurons mediated by astrocytic YAP through Wnts/β-catenin/EAAT2 signaling to prevent glutamate excitotoxicity of neurons in ALS mice, and provide a novel drug target for ALS.