Nanodelivery of Y-27632 by RGD-modified liposome enhances radioimmunotherapy of hepatocellular carcinoma via tumor microenvironment matrix stiffness reprogramming

作者：Yang Shen, Zihui Zheng, Xinyao Hu, Zhuolin Zhou, Yangtao Xu, Siyu Wang, Shu‐Hong Yu, Xiaoqin He, Ximing Xu · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.114892 · 被引用次数：8 · 研究领域：Nanoplatforms for cancer theranostics、Immune cells in cancer、Cancer Research and Treatments

RGD@LP-Y enhances RT sensitivity by remodeling ECM stiffness, modulating the hypoxia and immunosuppressive conditions within TME, and enhancing the ICD. The study provides a safe combinatorial approach for HCC therapy.