Skeletal editing of pyridines to aryldialdehydes

作者：Meixin Yan, Yonglin Shi, Cong Lv, Shunyao Huang, Shun Li, Dexi Yang, Jiangui Zhao, Zhishan Su, Weidong Jiang, Weichao Xue, Jiaqi Xu, Xueli Zheng, Ruixiang Li, Hua Chen, Haiyan Fu · 发表于：Nature Communications · 年份：2025 · DOI：10.1038/s41467-025-62627-8 · 被引用次数：9 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Chemical Synthesis and Analysis

Electron-deficient nitrogen-containing aromatic heterocycles, particularly pyridine derivatives, can be converted into all-carbon aromatic frameworks via the ANRORC (Addition of Nucleophile, Ring-Opening, and Ring-Closing) skeletal editing process, providing a convenient tool for molecular diversification. However, reported methods are mainly limited to nucleophilic modification of ring-opening species. Herein, we report a distinct electrophilic modification method, smoothly converting pyridines into arene-1,3-dialdehydes or naphthalene-1,3-dialdehydes. Electron-deficient nitrogen-containing aromatic heterocycles can be converted into all-carbon aromatic frameworks via skeletal editing but reported methods are mainly limited to nucleophilic modification of ring-opening species. Here the authors report an electrophilic modification method which converts pyridines into arene-1,3-dialdehydes or naphthalene-1,3-dialdehydes.