Trends of the burden, risk factors, and future projections of peripheral artery disease in the elderly

作者：Xiang Chen, Wenqiang Wang, Shunan Dong, Wei Lu, Puxiang Zhen, Yan Mo, Xinyu Nie, Qikai Hua · 发表于：BMC Geriatrics · 年份：2025 · DOI：10.1186/s12877-025-06228-6 · 被引用次数：6 · 研究领域：Peripheral Artery Disease Management、Renal and Vascular Pathologies、Cerebrovascular and Carotid Artery Diseases

BACKGROUND: Elderly individuals have a higher burden of peripheral arterial disease (PAD), but currently, there are no global reports on the disease burden of PAD in patients aged 60 and above. METHODS: This study analyzed data on elderly patients with PAD from 1990 to 2021 using the Global Burden of Disease (GBD) database, focusing on prevalence, mortality, and Disability-Adjusted Life Years (DALYs). We summarized the trends in disease burden across 21 GBD regions and 204 countries and projected the global burden for the next 20 years. RESULTS: Between 1990 and 2021, the prevalence cases of elderly PAD individuals worldwide increased by 105%, from 42,618,313 to 87,523,486. However, the Age-standardized prevalence rate (ASPR) decreased to 8,220.2 cases per 100,000 population (95% UI: 6,717.3-9,995.7), with an Estimated Annual Percentage Change (EAPC) of -0.52 (95% CI: -0.56 to -0.48). Similar trends were observed in mortality and DALYs. In 2021, elderly individuals represented 77% of PAD prevalence cases and 94% of related mortality cases. The ASPR for women was 1.7 times higher than for men, yet women experienced a lower mortality rate and DALY rate, suggesting a heavier overall disease burden. The disease burden increased with the Socio-Demographic Index (SDI), with the fastest growth observed in Low and Low-middle SDI regions. Among the GBD regions, High-Income North America and Western Europe had the highest burden, with the United States bearing the heaviest burden of al...