Long term efficacy and safety of MICT of cardiopulmonary function in patients after TAVR extended follow up of ENERGY study

作者：Yushan Li, Qiang Ren, Xing-Bo Mu, Kai Xu, Yanchun Liang, Jian Zhang, Geng Wang, Yanxia Wang, Cailian Wang, Yi Zhang, Shengyi Wang, Quanyu Zhang, Yaling Han · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-13451-z · 被引用次数：2 · 研究领域：Cardiac Valve Diseases and Treatments、Cardiovascular Function and Risk Factors、Cardiac Imaging and Diagnostics

The ENERGY study demonstrated that 3-month moderate-intensity continuous training (MICT) improved the cardiopulmonary function and exercise capacity for patients after transcatheter aortic valve replacement (TAVR). However, the long-term effects remained uncertain. Therefore, the present study evaluated the long-term efficacy and safety of MICT in patients undergoing TAVR. 64 patients were randomized into MICT (3 times per week) or control groups (one-time physical activity advice). Outcomes were assessed using the 12-month changes in cardiopulmonary exercise testing (CPET) parameters, 6-minute walk test (6MWT), SF-12 quality of life score, New York Heart Association (NYHA) class, echocardiographic and laboratory parameters. After 12 months, the MICT group showed significantly greater improvements in peak VO 2 (1.61 ml/kg/min, 95% CI 0.10 to 3.12, P = 0.037), peak MET (0.56, 95% CI 0.20 to 0.93, P = 0.003), VO 2 AT (1.55 ml/kg/min, 95% CI 0.80 to 2.30, P < 0.001), METAT (0.35, 95% CI 0.10 to 0.61, P = 0.007), peak O 2 pulse (1.04 mL/beat, 95% CI 0.03 to 2.05, P = 0.044), 6MWT (21.24 m, 95% CI 7.10 to 35.39, P = 0.004), and mental component summary of SF-12 (10.47, 95% CI 0.48 to 20.45, P = 0.040) compared to control group. Long-term MICT safely and effectively enhances the cardiopulmonary function and quality of life in patients after TAVR.