Harnessing clonal diversity in grapevine: from genomic insights to modern breeding applications

作者：Paolo Callipo, Maximilian Heinrich-Wilhelm Schmidt, Timo Strack, Hannah Robinson, Akshaya Vasudevan, Kai P. Voss‐Fels · 发表于：Theoretical and Applied Genetics · 年份：2025 · DOI：10.1007/s00122-025-04986-w · 被引用次数：15 · 研究领域：Horticultural and Viticultural Research、Plant biochemistry and biosynthesis、Plant and animal studies

Grapevine has been clonally propagated for thousands of years. Though clonal propagation aims at maintaining varietal identity, somatic mutations and epigenetic modifications accumulated over hundreds to thousands of years lead to intra-varietal diversity. This intra-varietal variation is a very valuable resource in grapevine breeding, as it creates the opportunity to improve important traits related to yield, phenology, stress tolerance, and quality without altering the varietal identity which is extremely important for the industry. Recent advances in genomics, epigenetics, and phenotyping technologies are providing completely new opportunities to gain functional insights into the drivers underlying trait variation and to explore this for accelerated grapevine breeding. This review discusses the interaction between somatic mutations, epigenetic regulation, and emerging breeding technologies. We begin by exploring the phenotypic variation observed within clonal populations across various commercially important varieties, focusing on both agronomic and winemaking-related traits. Next, we examine the extent of genomic and epigenomic variation among clones, highlighting known mutations responsible for somatic variants. We also address how grapevine clonal populations serve as an advantageous model for understanding how genetic and epigenetic variants shape complex trait variation. Given recent advances, we discuss the potential of predictive breeding strategies to accelerate cl...