The glucose sensor NSUN2-m 5 C modification regulates tumor-immune glucose metabolism reprogramming to drive hepatocellular carcinoma evolution

作者：Jing He, Boqiang Liu, Weijun Zhao, Hao Shen, Junqing Wang, Weiqi Li, Chenqi Jin, Yifan Wang, Xiujun Cai, Liang Shi · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.115610 · 被引用次数：11 · 研究领域：Cancer, Hypoxia, and Metabolism、Pancreatic function and diabetes、RNA modifications and cancer

T cell dysfunction. Building on these insights, we designed a dual-targeting strategy combining GLUT1/NSUN2 axis inhibitor WZB117 with PD-L1 blockade, which synergistically suppressed tumor evolution and reversed immunosuppression in preclinical models, suggesting a novel synergistic therapeutic strategy for treatment-resistant HCC.