Tissue Factor Pathway Inhibitor 2 Enhances Hepatocellular Carcinoma Chemosensitivity by Activating CCAR2-GADD45A-Mediated DNA Damage Repair

作者：Hongzhong Zhou, Liwen Zhu, Yajun Zhang, Lichan Chen, Dongmei Gou, Haohua Zhang, Rongmao Hua, Jianning Song, Chuanghua Qiu, Fu-Wen Yao, Xiafei Wei, Dayong Gu, Yong Xu · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.111142 · 被引用次数：6 · 研究领域：Nuclear Receptors and Signaling、RNA Interference and Gene Delivery、Cancer-related gene regulation

. TFPI2 plays a critical role in CCAR2-GADD45A-induced DNA damage repair, providing a strategy to enhance HCC chemosensitivity. Our findings elucidate the molecular intricacies of chemoresistance in HCC and reveal a potential therapeutic target for alleviating this resistance.