Ferroptosis-Resistant Adipocytes Drive Keloid Pathogenesis via GPX4-Mediated Adipocyte-Mesenchymal Transition and Iron-Cystine Metabolic Communication

作者：Xiangguang Shi, Xueyi Xia, Yang Xiao, Huizhen Shu, Zhuoya Xu, Mengguo Liu, Chenyi Shi, Ying Zhang, Yining Wei, Yiyi Gong, Wei Wang, Yahui Chen, Jian-Lan Liu, Jia Huang, Mengkun Shi, Jiucun Wang, Wenyu Wu · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.114930 · 被引用次数：5 · 研究领域：Dermatologic Treatments and Research、Biomarkers in Disease Mechanisms、Kruppel-like factors research

The findings establish ferroptosis modulation (via RSL3 or iron chelation) as a promising therapeutic strategy for keloids, offering potential new treatments for this recalcitrant condition.