Epigenetic orchestration of RNA m 6 A methylation in wound healing and post-wound events

作者：Heao Zhang, Delong Gao, Z. Li, Sis Aghayants, Yiping Wu, Zeming Liu, Qi Zhang · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.114988 · 被引用次数：9 · 研究领域：RNA modifications and cancer、Cancer-related gene regulation、Autophagy in Disease and Therapy

Skin, the largest human organ, demonstrates remarkable regenerative capacity through spatiotemporally coordinated healing processes.Chronic wounds, including diabetic ulcers and burn injuries pose significant clinical challenges due to persistent inflammation, impaired angiogenesis, defective appendage regeneration, and pathological scarring.Emerging evidence reveals N 6 -methyladenosine (m 6 A) methylation -the most prevalent RNA modification -as a critical regulator of wound healing and tissue remodeling.The m 6 A machinery (writers, readers, erasers) dynamically controls RNA stability, translation, and splicing, thereby modulating keratinocyte migration, fibroblast activation, macrophage polarization, and stem cell differentiation.Dysregulated m 6 A dynamics impair diabetic wound healing through oxidative stress amplification and autophagy deficiency, while disrupting critical repair pathways in burn injuries.Aberrant m 6 A modifications exacerbate pathological scarring and dysfunctional appendage regeneration via dysregulated extracellular matrix deposition and fibroblast dysfunction.Current understanding of m 6 A spatiotemporal regulation and clinical potential remains fragmented despite significant advances.Future investigations integrating single-cell sequencing, spatial transcriptomics, and multidisciplinary approaches are crucial to decode the multifaceted roles of m 6 A, enabling the development of novel epitranscriptome-targeted therapies for chronic wound manageme...