Sex‐Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild‐Based Analysis and Implications for Healthy Aging

作者：Jiongxing Fu, Wanghong Xu, Danxia Yu, Yu Jiang, Lei Wang, Hui Cai, Qinghua Xia, Xiao‐Ou Shu, Wei Zheng · 发表于：Aging Cell · 年份：2025 · DOI：10.1111/acel.70192 · 被引用次数：2 · 研究领域：Gut microbiota and health、Dietary Effects on Health、Diet and metabolism studies

ABSTRACT Gut microbial stability typically decreases with physiological aging. This decline may vary between sexes and can potentially be mitigated by adopting a healthy lifestyle. Microbial guilds, defined as functionally coherent groups of bacteria, may serve as meaningful ecological indicators of aging. This study included 2944 participants aged 51–89 years from the Shanghai Men's and Women's Health Studies. Using 16S rRNA gene sequencing and a guild‐based approach, we evaluated the associations between gut microbiota and age in 1353 relatively healthy individuals. We found that women demonstrated a decline in the Chao1 index, an increase in Pielou evenness, and a remarkable shift in Bray–Curtis distance, whereas men exhibited an increase in Bray–Curtis uniqueness. Of the 45 age‐related guilds identified, 16 (8 in men and 10 in women) were considered potential aging biomarkers ( p FDR < 0.05), with Guild_6 ( Bifidobacterium sp. dominated) and Guild_118 ( Veillonella dispar dominated) being common to both sexes. These guilds were associated with consistent predicted functions, particularly 1,4‐dihydroxy‐2‐naphthoate biosynthesis. We estimated sex‐specific microbial age using random forest models and found that women and individuals with major chronic diseases had higher microbial ages. Prospective analysis revealed that an “old” microbial age was associated with a higher risk of type 2 diabetes (HR = 2.0, 95% CI: 1.1, 3.7). Individuals with healthier lifestyles had a 0.4...