The impact of neighborhood-level disadvantage on symptoms, mood, and health-related quality of life among the primary brain tumor population

作者：Zuena Karim, Kimberly Robins, Orieta Celiku, Yeon-Ju Kim, Hope Miller, Elizabeth Vera, Jacqueline B. Vo, Mark R. Gilbert, Terri S. Armstrong, Macy Stockdill · 发表于：Neuro-Oncology Practice · 年份：2025 · DOI：10.1093/nop/npaf069 · 被引用次数：2 · 研究领域：Cancer survivorship and care、Cancer-related cognitive impairment studies、Childhood Cancer Survivors' Quality of Life

Abstract Background Evidence assessing the impact of neighborhood-level disadvantage and population density on outcomes of individuals with cancer is growing but has not been evaluated among the primary brain tumor (PBT) population. We evaluated associations of neighborhood-level disadvantage and population density with symptoms and health-related quality of life (HRQOL) among adults with a PBT. Methods Neighborhood-level disadvantage, measured using the Area Deprivation Index (ADI), and population density were evaluated against symptoms (MDASI-BT and PROMIS Anxiety/Depression Short Forms v1.0 8a) using linear regression models and against HRQOL (EQ-5D-3L) using logistic regression models. Models were adjusted for age, sex, race/ethnicity, tumor grade, functional status, and tumor recurrence. Results were further stratified by tumor grade. Results Of 643 participants, 24% lived in more disadvantaged neighborhoods, while 39% resided in non-urbanized areas. Patients in more disadvantaged neighborhoods reported greater symptom severity (β = 1.10, 95%CI [1.00, 1.20], P = .041) and activity-related interference (β = 1.11, 95%CI [1.01, 1.22], P = .03) than those in less disadvantaged neighborhoods. Among patients with low-grade tumors, living in more disadvantaged neighborhoods was associated with worse symptom interference (β=1.24, 95%CI [1.04, 1.50], P = .020), anxiety (β=1.03, 95%CI [1.01, 1.06], P = .023), and difficulties with mobility (OR = 3.30, 95%CI [1.09, 10.01], P = .035...