Research progress of PYK2 in digestive system diseases

作者：Yajuan Duan, Mingzhu Xie, Hui Wang, Sijing Chen, Jun Hu, Xujia Chen, Hong Ping Jia, Ningyan Zhang, Ling Peng, Xiang Li, Hameed Ullah Khan, Die Hu, Rong Qin · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2025.1614589 · 被引用次数：2 · 研究领域：Cell Adhesion Molecules Research、Angiogenesis and VEGF in Cancer、Cancer Cells and Metastasis

Belonging to the focal adhesion kinase (FAK) family, proline-rich tyrosine kinase 2 (PYK2) is a non-receptor tyrosine kinase, has become a focal point in cancer research owing to its essential participation in the formation and dissemination of tumors. Studies have shown that this kinase controls various cellular activities, including: tumor cell adhesion, growth, multiplication, specialization, and detachment, making it a promising target for developing anticancer drugs. The goal of this review is to analyze the multifaceted role of PYK2 in gastrointestinal disease, focusing on its contribution to tumor progression, associated signaling pathways, and the therapeutic potential of PYK2 inhibitors in improving disease management and prognosis.