Atypical presentation of occupational mpox: a case report from Brazil

作者：Guilherme S. Lira, Mariana Q. S. Melo, Isabela C. Leitão, Matheus V. Andrade, Anna Carla Castiñeiras, Diana Mariani, Cássia Cristina Alves Gonçalves, Lendel Correia da Costa, Danielle A. S. Rodrigues, André M. Vale, Filipe Romero Rebello Moreira, Carolina Moreira Voloch, Débora S. Faffe, Luiza M. Higa, Rafael Mello Galliez, Clarissa R. Damaso, Amílcar Tanuri, Terezinha Marta Pereira Pinto Castiñeiras · 发表于：ASM Case Reports · 年份：2025 · DOI：10.1128/asmcr.00104-24 · 被引用次数：1 · 研究领域：Poxvirus research and outbreaks、Virology and Viral Diseases、Bacillus and Francisella bacterial research

Background: After decades of circulating predominantly in Africa, mpox caused a public health emergency of international concern between 2022 and 2023. Even outside of the epidemic period, the virus still circulates, with threats of reemergence, and different clinical presentations must be brought to attention for optimal surveillance. Case Summary: We report a case of monkeypox virus (MPXV) infection in a previously healthy physician with an atypical clinical presentation and a single identified exposure. Diagnosis was confirmed by PCR. Viral isolation was employed to reinforce diagnosis. Plaque reduction neutralization assays and semiquantitative ELISA were used to evaluate the antibody response. Conclusion: Our report has two main messages: atypical symptoms of mpox can hinder diagnosis, making adequate suspicion and testing fundamental; and the risk of occupational exposure must be considered when designing policies for healthcare workers.