Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adults

作者：Myriam Fornage, Wassim Tarraf, Martha L. Daviglus, Charles DeCarli, Kevin A. González, Carmen R. Isasi, Sayaka Kuwayama, Melissa Lamar, Bonnie Levin, Humberto Parada, Alberto R. Ramos, Tatjana Rundek, Bharat Thyagarajan, Hector M. González · 发表于：Clinical Epigenetics · 年份：2025 · DOI：10.1186/s13148-025-01941-w · 被引用次数：5 · 研究领域：Epigenetics and DNA Methylation、Alzheimer's disease research and treatments、Dementia and Cognitive Impairment Research

Blood-based biomarkers hold significant promise for the early detection and diagnosis of Alzheimer’s disease (AD) and other dementias. Age-related changes in blood levels of AD biomarkers are well-documented but poorly understood. Epigenetic clocks are mathematical models based on DNA methylation patterns that reflect various aspects of the multidimensional aging process. We investigated the associations of epigenetic aging with five blood-based AD biomarkers in 2656 Hispanic/Latino adults (mean age 62.5 years; 65% females) from the Hispanic Community Health Study/Study of Latinos. We used multivariable linear regression models to estimate the associations of acceleration in each of five epigenetic clocks with each biomarker in the total sample and in sex-specific strata, controlling for chronological age, sex (except in sex-stratified analyses), Hispanic/Latino background, recruitment site, risk factors, and comorbid medical conditions. There were varying strengths of association between acceleration of the clocks and the plasma biomarkers. There were significant associations of acceleration in all epigenetic clocks with higher plasma levels of neurofilament light chain (NfL) (Beta = 0.0045 to 0.0193; P = 0.022 to 4.9 × 10 –15 ). There were significant associations of acceleration in all epigenetic clocks except DunedinPACE with higher plasma levels of amyloid beta (Aβ)40 (Beta = 0.0033 to 0.0049; P = 0.024 to 1.7 × 10 –5 ). PC-PhenoAge acceleration was associated with all c...