Unveiling the potential of Lactobacillus johnsonii in digestive diseases: a comprehensive review

作者：Jinjie Zhou, Shuang Ma, Zhuo Huang, Qinyan Yao, Zihan Yu, Jihua Chen, Liuqing Yao, Lanping Zhu, Xin Chen · 发表于：Frontiers in Microbiology · 年份：2025 · DOI：10.3389/fmicb.2025.1508382 · 被引用次数：8 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Gastrointestinal motility and disorders

Background Lactobacillus johnsonii ( L. johnsonii ) is a lactic acid-producing probiotic, possessing the potential to modulate intestinal microbiota balance, which can enhance immune function, and reduce the risk of intestinal infections. In recent years, increasing studies have demonstrated the positive impact of this strain and its metabolites on the health of multiple systems, including the stomach, intestine, liver, and brain. Objective This article aims to systematically review the mechanisms of action and clinical application progress of L. johnsonii in the prevention and treatment of digestive system-related diseases. The focus is on exploring its systemic regulatory role through the “microbiota-gut-organ axis.” Methodology By collating and analyzing recent research findings on L. johnsonii , we evaluated its specific mechanisms in regulating intestinal barrier function, immune response, and neuroendocrine signaling pathways. This strain can be isolated and identified through experimental means, and its population abundance can be quantitatively analyzed, providing a basis for studying its biological functions. Results Studies have revealed that L. johnsonii exhibits significant interventional potential in various cross-system diseases, including inflammatory bowel disease (IBD), intestinal infections, Helicobacter pylori ( H. pylori )-associated gastritis, non-alcoholic fatty liver disease, and neurodegenerative diseases. These findings further validate the important ...