Comparison of Phonomyography Prototype With Train-of-Four Watch SX for Neuromuscular Monitoring: A Prospective Observational Study

作者：Yanjie Dong, Yi Yang, Weichao Guo, Shuangwen Wang, Hui Yang, Qian Li · 发表于：Anesthesia & Analgesia · 年份：2025 · DOI：10.1213/ane.0000000000007648 · 被引用次数：2 · 研究领域：Anesthesia and Sedative Agents、Intraoperative Neuromonitoring and Anesthetic Effects、Cardiac pacing and defibrillation studies

BACKGROUND: Quantitative neuromuscular monitoring has been advocated to deal with residual neuromuscular block. Phonomyography (PMG) is a technology that captures the acoustic signals yielded by muscle contraction, which is easy to use, anti-interference, and has multiple alternative monitoring sites. Our previous study has developed a PMG prototype for neuromuscular monitoring, and its feasibility was preliminarily verified, but further study on its clinical reliability with different neuromuscular blocking agents (NMBs) is needed. METHODS: This single-center, prospective, observational study compared the effect of a PMG prototype and TOF-Watch SX on neuromuscular monitoring of the ipsilateral adductor pollicis muscle with the use of non-depolarizing and depolarizing NMBs among 102 surgical patients. Patients were divided into 3 groups by NMBs, namely Group C (cisatricurium), Group V (vecuronium), and Group S (succinylcholine). The PMG prototype and TOF-Watch SX were placed at ipsilateral hand of each individual and measured data from NMBs administration to a stable train-of-four ratio (TOFr) ≥ 0.9 or T value ≥ 0.9 were compared. RESULTS: Eighty patients were included in the data analysis. For non-depolarizing NMBs, the PMG prototype recorded a longer onset time compared to TOF-Watch SX (median [interquartile range, IQR], 210 [180-240] seconds vs 150 [135-180] seconds, P < .001, mean bias 48 [40-55]; mean ± [standard deviation, SD], 197 ± 48 seconds vs 159 ± 36 seconds, P < ...