Global, regional, and national burden of maternal disorders, 1990–2021: a systematic analysis from the global burden of disease study 2021

作者：Jie Huang, Yuanyuan Man, Zan Shi, Xiaorui Fu, Wenhao Shi, Xiaoling Liang · 发表于：BMC Public Health · 年份：2025 · DOI：10.1186/s12889-025-23814-w · 被引用次数：27 · 研究领域：Global Maternal and Child Health、Pregnancy and preeclampsia studies、Maternal and fetal healthcare

BACKGROUND: Maternal morbidity and mortality, encompassing pregnancy-related complications and obstetric disorders, pose a persistent global health challenge with significant multigenerational consequences. As the second leading cause of disability-adjusted life years (DALYs) among women of reproductive age globally, these conditions exert profound impacts on perinatal outcomes and intergenerational health equity. The Global Burden of Disease Study (GBD), recognized as the most comprehensive epidemiological surveillance system, provides critical evidence for optimizing maternal health policies through systematic quantification of disease burden patterns. This multinational study employs GBD 2021 data to conduct a spatiotemporal analysis of maternal disorder burden across 21 GBD regions and 204 countries and territories from 1990 to 2021, utilizing standardized metrics including DALYs, prevalence rates, and mortality incidence. METHODS: This population-based multinational investigation employed systematically collected epidemiological evidence from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2021, with data acquisition was conducted through the standardized Global Health Data Exchange platform ( https://vizhub.healthdata.org/gbd-results/.GBD Results Tool; data retrieval date: November 11, 2024). We systematically analyzed temporal trends in maternal disorder burden from 1990 to 2021 using a standardized analytical framework stratified across three dim...