A novel endoscopic suture anchor device for large mucosal defect closure in an in vivo porcine model

作者：Jiancong Feng, Yaqi Zhai, Zhenyu Liu, Enqiang Linghu · 发表于：Endoscopy · 年份：2025 · DOI：10.1055/a-2650-9543 · 被引用次数：2 · 研究领域：Surgical Sutures and Adhesives、Esophageal and GI Pathology、Tracheal and airway disorders

Closure of large mucosal defects following endoscopic submucosal dissection is essential in interventional endoscopy [ 1 ]. While multiple closure systems have emerged, their clinical implementation remains constrained by technical complexity and high costs [ 2 ] [ 3 ], highlighting the need for simple and cost-effective closure devices. Our research team has designed a novel endoscopic suture anchor device, developed from a conventional through-the-scope clip ([ Fig. 1 ]). It is compatible with 3.2-mm working channels and integrates sutures for defect closure. This study evaluated the feasibility of the suture anchor device for closing large mucosal defects in an in vivo porcine model. Fig. 1 A novel endoscopic suture anchor device (fabricated by Micro-Tech, Nanjing, China). Defect closure was performed according to the following steps ([ Video 1 ]). The first suture anchor, pre-secured with a suture, is delivered via the working channel to the mucosal defect margin ([ Fig. 2 ] a ). The handle is rotated to drive the anchor into the tissue and then pressed to release the anchor. The second anchor is threaded through the suture and released on the contralateral defect margin via the working channel in the same manner. Tension is applied to the suture to eliminate slack ([ Fig. 2 ] b ), then the suture anchors are positioned in a zigzag pattern ([ Fig. 2 ] c ). Finally, moderate tension is applied to the suture to approximate the defect edges; the suture is then cut with a sut...