Macrophages in rosacea: pathogenesis and therapeutic potential

作者：Xiaolin Wang, Huanyu Shi, Xueli Li, Yanyan Feng · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2025.1595493 · 被引用次数：8 · 研究领域：Acne and Rosacea Treatments and Effects、Pharmacological Effects of Natural Compounds、Dermatologic Treatments and Research

Objective: Rosacea is a chronic inflammatory dermatosis predominantly affecting the central face, with its pathogenesis not yet fully elucidated. Macrophages, as innate immune cells in the human body, play a crucial role in inflammatory responses. However, the specific mechanistic role of macrophages in rosacea remains incompletely understood. This review aims to comprehensively analyze and discuss the functions of macrophages, their involvement in the pathogenesis of rosacea, and their potential as therapeutic targets. Method: A systematic literature search was conducted using keywords such as "rosacea" and "macrophage" in databases including PubMed and Web of Science, without restrictions on article type or publication date, to ensure a comprehensive retrieval of relevant studies. Additionally, the references cited in the retrieved articles were manually searched to gather further pertinent knowledge. Results: For the articles obtained from the database searches, we focused solely on those that mentioned the role of macrophages in rosacea and related therapeutic approaches to ensure the accuracy of the content. Ultimately, 121 articles were selected for inclusion in this review, encompassing review articles, original research studies, meta-analyses, and other types of publications. Conclusion: This review summarizes the latest research progress on the role of macrophages in the pathogenesis of rosacea, emphasizing their significant involvement through the regulation of immu...