Estimating the longitudinal association between pain characteristics and clinical outcomes in young people with mental ill-health

作者：Valerie A Oosterwijk, Caroline X. Gao, Jana M Menssink, Josh Nguyen, Kate Filia, Amity Watson, Helen Herrman, Sarah Hetrick, Alexandra Parker, Ian B. Hickie, Debra Rickwood, Patrick D. McGorry, Susan M. Cotton, Lianne Schmaal, Scott D. Tagliaferri · 发表于：Psychological Medicine · 年份：2025 · DOI：10.1017/s0033291725101104 · 被引用次数：4 · 研究领域：Pediatric Pain Management Techniques、Childhood Cancer Survivors' Quality of Life、Mental Health Treatment and Access

Abstract Background Mental ill-health has a major impact on young people, with pain often co-occurring. We estimated the prevalence and impact of pain in young people with mental ill-health. Methods Longitudinal data (baseline and three-month follow-up) of 1,107 Australian young people (aged 12–25 years) attending one of five youth mental health services. Multi-level linear mixed models estimated associations between pain characteristics (frequency, intensity, and limitations) and outcomes with false discovery rate (FDR) adjustment. Pain characteristics were baseline-centered to estimate if the baseline score ( between-participant effect ) and/or change from baseline ( within-participant effect) was associated with outcomes. Results At baseline, 16% reported serious pain more than 3 days, 51% reported at least moderate pain, and 25% reported pain-related activity limitations in the last week. Between participants, higher serious pain frequency was associated with greater anxiety symptoms ( β [95%CI]: 0.90 [0.45, 1.35], FDR-p=0.001), higher pain intensity was associated with greater symptoms of depression (1.50 [0.71, 2.28], FDR-p=0.001), anxiety (1.22 [0.56, 1.89], FDR-p=0.002), and suicidal ideation (3.47 [0.98, 5.96], FDR-p=0.020), and higher pain limitations were associated with greater depressive symptoms (1.13 [0.63, 1.63], FDR-p<0.001). Within participants, increases in pain intensity were associated with increases in tobacco use risk (1.09 [0.48, 1.70], FDR-p=0.002)...