Left Atrial Volumetric/Mechanical Coupling Index in Heart Failure With Preserved Ejection Fraction

作者：Masato Okada, Nobuaki Tanaka, Katsuomi Iwakura, Toshinari Onishi, Masahiro Seo, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Shunsuke Tamaki, Yoshio Yasumura, Takahisa Yamada, Daisuke Sakamoto, Shungo Hikoso, Katsuki Okada, Daisaku Nakatani, Yohei Sotomi, Yasushi Sakata, the OCVC‐Heart Failure Investigators · 发表于：Journal of the American Heart Association · 年份：2025 · DOI：10.1161/jaha.124.040646 · 被引用次数：8 · 研究领域：Cardiovascular Function and Risk Factors、Heart Failure Treatment and Management、Cardiovascular Disease and Adiposity

Background Left atrial (LA) dysfunction is common in heart failure with preserved ejection fraction (HFpEF). The LA volumetric/mechanical coupling index (LACI), calculated as the LA volume index divided by the late diastolic mitral annular velocity (a′), is a recently advocated parameter reflecting LA contractile function based on the atrial Frank–Starling mechanism. An elevated LACI signifies impaired mechanical performance despite greater atrial volume, indicating volumetric/mechanical uncoupling. Its associations with echocardiographic indices and prognostic significance in HFpEF remain unclear. Methods This study included 562 patients from the PURSUIT‐HFpEF (Prospective Multicenter Observational Study of Patients With Heart Failure With Preserved Ejection Fraction) registry, a prospective multicenter registry for HFpEF. LACI was calculated and categorized into quartiles. Associations with echocardiographic indices and clinical outcomes were examined. Results LA volume index and late diastolic mitral annular velocity were negatively correlated ( r =−0.26; P <0.001), reflecting impaired atrial Frank–Starling mechanism in this cohort. The median LACI was 6.44 (interquartile range, 4.16–9.69). Patients with elevated LACI had unfavorable backgrounds with increased filling pressure and diastolic dysfunction. During a median follow‐up of 40 months, 171 patients experienced cardiovascular death or rehospitalization for heart failure, with event incidence increasing across LACI...