Racial and Ethnic Disparities in Survival among Patients with Cholangiocarcinoma in the United States: A Systematic Review and Meta-analysis

作者：Andrew D. Shubin, Phillip J. Leff, Meena M. Tadros, Meng‐Lun Hsieh, David Hsiehchen, Parsia A. Vagefi, Jason Y. Wang, Gonzalo Sapisochín, Adam Charles Yopp, Nina Niu Sanford, Ju Dong Yang, Amit G. Singal, Madhukar S. Patel, Nicole E. Rich · 发表于：Cancer Epidemiology Biomarkers & Prevention · 年份：2025 · DOI：10.1158/1055-9965.epi-25-0634 · 被引用次数：3 · 研究领域：Cholangiocarcinoma and Gallbladder Cancer Studies、Gallbladder and Bile Duct Disorders、Pancreatic and Hepatic Oncology Research

BACKGROUND: Cholangiocarcinoma (CCA) is an increasing cause of mortality in the United States; however, the burden of CCA disproportionately affects racial and ethnic minority groups. We aimed to characterize racial and ethnic differences in stage, treatment, and survival among patients with CCA. METHODS: We systematically searched MEDLINE and Embase through March 2023 for all studies reporting clinical outcomes among patients with CCA stratified by race and ethnicity. We calculated pooled HRs using the DerSimonian and Laird method for a random-effects model. RESULTS: Of 292 articles, 16 met inclusion criteria (n = 248,109 patients). Among six studies (n = 87,938) reporting overall survival, Black patients had worse survival [pooled HR, 1.05; 95% confidence interval (CI), 1.01-1.10], whereas Hispanic (pooled HR, 0.86; 95% CI, 0.83-0.89) and Asian/Pacific Islander (pooled HR, 0.88; 95% CI, 0.85-0.90) patients had better survival than White patients. Compared with White patients, Black and Hispanic patients were less likely to present at an early stage, and Black patients were less likely to undergo resection (pooled OR, 0.69; 95% CI, 0.63-0.75). The limitations of studies were lack of granularity on subtype and risk of residual confounding. CONCLUSIONS: There are racial and ethnic differences in CCA prognosis in the United States, with Black patients having worse survival and Hispanic and Asian patients having better survival than White patients. Studies are needed to identify...