Beyond Comorbidity: Pulmonary Adenocarcinoma in a Patient with Rheumatoid Arthritis—A Case Report and Literature Review

作者：Ancuța-Alina Constantin, Mihai Alexandru Arghir, Dana Avasilcăi, Florin Mihălţan · 发表于：Life · 年份：2025 · DOI：10.3390/life15071118 · 被引用次数：1 · 研究领域：Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、Sarcoidosis and Beryllium Toxicity Research、Lung Cancer Treatments and Mutations

Lung cancer is one of the most common and deadly forms of cancer worldwide, despite sustained efforts to encourage smoking cessation and raise awareness of the risk factors. In Romania, lung cancer is a significant health challenge, being the leading cause of death caused by cancer, especially amongst men. The incidence of lung cancer in connective tissue disease (CTD) varies in different studies from 4.5% in rheumatoid arthritis (RA), to 4.4% in polymyositis or dermatomyositis, and up to 11.1% in systemic sclerosis. However, older studies have shown an increased risk of cancer in patients with rheumatoid arthritis (RA), ranging from 10% to 30% compared to the general population, particularly in those undergoing methotrexate therapy. Rheumatoid arthritis affects approximately 40 per 100,000 people annually worldwide, with a three- to four-fold higher incidence in women. Non-small cell lung cancer (NSCLC), the most common lung cancer subtype, has been linked to RA, yet the association remains poorly defined, with limited insight into the underlying molecular mechanisms. We present the case of a 61-year-old male with a 49-pack-year smoking history and a known diagnosis of rheumatoid arthritis, currently managed with methotrexate therapy. He was admitted for evaluation due to a progressive decline in general condition, characterized by worsening dyspnea and chest pain, symptoms that had been longstanding but had markedly exacerbated over the past two weeks. Based on a chest CT p...