Estimation of multicomponent flow in the kidney with multi‐ b ‐value spectral diffusion

作者：Mira Liu, Thomas Gladytz, Jonathan P. Dyke, Ian Bolger, Jonas Jasse, Sergio Calle, Tanner Crews, Surya V. Seshan, Steven Salvatore, Isaac E. Stillman, Thangamani Muthukumar, Bachir Taouli, Samira Farouk, Octavia Bane, Sara Lewis · 发表于：Magnetic Resonance in Medicine · 年份：2025 · DOI：10.1002/mrm.30644 · 被引用次数：7 · 研究领域：MRI in cancer diagnosis、Advanced MRI Techniques and Applications、NMR spectroscopy and applications

Abstract Purpose Examine the theory and potential clinical application of estimated intravoxel “flow” of separated perfusion, tubular flow, and tissue diffusion from multi‐ b ‐value DWI in kidney allografts. Methods Multi‐ b ‐value DWI (nine b ‐values; 0–800 s/mm 2 ) from a kidney cortex is simulated with anisotropic and non‐Gaussian (i.e., anomalous) vascular, tubular, and tissue components and analyzed with a Bayesian biexponential, least‐squares triexponential, and spectral diffusion MRI. Comparison and application of biexponential, triexponential, and spectral diffusion flow proxies as the product of signal fraction and diffusion coefficient , for each component, is demonstrated in a two‐center study of 54 kidney allografts patients (21 females/33 males, 48.8 ± 10.5 years, NCT05058170) and compared to fibrosis (Banff 2017 interstitial fibrosis and tubular atrophy score 0–6 from clinical biopsies of the renal cortex), impaired kidney function (Chronic Kidney Disease Epidemiology Collaboration 2021 estimated glomerular filtration rate<45 mL/min/1.73 m 2 ), and proteinuria (mg/24 h). Results Spectral diffusion demonstrated strong correlation to input of the simulated anisotropic and anomalous components. It agreed with both three‐component diffusion (, ) and two‐component diffusion (). showed similar or improved agreement and correlation to input than the individual parameters and , and spectral diffusion showed similar or improved agreement than corresponding bi‐ and tri...