Intranasal administration of stem cell derivatives for the treatment of AD animal models: a systematic review and meta-analysis

作者：Zilin Hua, Nan Zhou, Zijing Zhou, Zewei Fu, Ruiyun Guo, Herman Yao Akogo, Jia-Yin Yang, Meixuan Yu, Yujie Jiang, Siyi Lan, Haixia Chang, Jun Ma, Huixian Cui · 发表于：Stem Cell Research & Therapy · 年份：2025 · DOI：10.1186/s13287-025-04555-4 · 被引用次数：11 · 研究领域：Mesenchymal stem cell research、MicroRNA in disease regulation、Extracellular vesicles in disease

BACKGROUND: Alzheimer’s disease (AD) is a neurodegenerative disorder with increasing prevalence and limited efficacy of current therapies. Stem cell-derived therapies have attracted attention for their potential neurodegenerative and reparative effects. Intranasal administration provides a non-invasive route that bypasses the blood-brain barrier and delivers stem cell derivatives directly to the brain. Although studies have shown that the intranasal administration of stem cell derivatives alleviates symptoms in animal models of AD, a comprehensive meta-analysis evaluating their therapeutic efficacy is yet to be conducted. This study aims to evaluate the efficacy of intranasal stem cell derivatives therapies in AD animal models and provide a foundation for clinical translation. METHODS: We conducted a systematic literature search across four databases (Pubmed, Embase, Web of Science and Cochrane Library) using subject terms and complementary keywords. After applying inclusion and exclusion criteria, data were extracted using Origin 2024 software and analysed using Review Mange 5.4. The SYRCLE tool was applied to assess study quality and evaluate the potential risk of bias systematically. RESULTS: This meta-analysis of 14 studies investigated the efficacy of intranasal stem cell-derived therapies in animal models of Alzheimer’s disease (AD). Using predominantly mouse and rat models from diverse geographical locations and employing various stem cell types (bone marrow, umbilical...