Cascade Biomineralization of Geometrically Tuned Osteon-Mimetic Composite Biovesicle-Hydrogel Coating Improves Ti Implant-Assisted Repair of Osteoporotic Bone Fractures

作者：Xinqiang Hu, Maohua Chen, Huocheng Yang, Hao Wei, Bikun Zhou, Menghuan Li, Zhong Luo, Kaiyong Cai, Yan Hu · 发表于：ACS Nano · 年份：2025 · DOI：10.1021/acsnano.5c08912 · 被引用次数：9 · 研究领域：Bone Tissue Engineering Materials、Connective tissue disorders research、Bone and Dental Protein Studies

influx and osteogenic differentiation of adherent osteoblasts, while the biovesicle-mediated in situ VD3 delivery could further boost cellular Ca/P metabolism and mineral precursor excretion to accelerate ECM mineralization. These functions could act in a cooperative manner to promote new bone formation at the bone-implant interface to accelerate Ti-based implant osteointegration, presenting a promising approach for osteoporotic bone fracture repair in the clinic.