Generation of induced pluripotent stem cells from 8 neurotypical individuals with elevated genetic risk for schizophrenia

作者：Sangho Myung, Srinidhi Rao Sripathy, Brady J. Maher · 发表于：Stem Cell Research · 年份：2025 · DOI：10.1016/j.scr.2025.103791 · 研究领域：Genomics and Rare Diseases、Genetic Associations and Epidemiology、Genomic variations and chromosomal abnormalities

Schizophrenia (SCZ) is a common and debilitating mental illness characterized by positive and negative symptoms, and impaired cognition. Genome-wide association studies (GWAS) have identified hundreds of genomic regions containing SCZ risk variants. For each individual, a polygenic risk score (PRS) can be derived, which is a metric of genetic susceptibility for SCZ. Here, we report the generation of human induced pluripotent stem cells (hiPSCs) from 8 neurotypical individuals with elevated PRS. These hiPSC lines will be useful to study common variant risk for SCZ and for the generation of isogenic lines containing rare variants associated with SCZ risk.