Multidimensional quality evaluation of Artemisia argyi as a medicinal crop: Phenotypic traits, chemical composition, and pharmacodynamic activity of wild and cultivated populations

作者：Wenli Xu, Le Chen, Jinglin Yang, Zhouyuan Li, Jingwen Ma, Xiang Xiao, Lei Mi, Jing Ming, Dahui Liu, Hongzhi Du · 发表于：Industrial Crops and Products · 年份：2025 · DOI：10.1016/j.indcrop.2025.121508 · 被引用次数：8 · 研究领域：Essential Oils and Antimicrobial Activity、Sesquiterpenes and Asteraceae Studies、Phytochemistry and Biological Activities

As a globally known medicinal crop, Artemisia argyi ( A. argyi ) is widely applied as industrial raw materials for pharmaceutical industries, with huge economic value. At present, commercial A. argyi comes from both wild and cultivated A. argyi . The quality of wild and cultivated A. argyi has gained a lot of attention. In this study, the comparison of phenotypic characteristics in 86 samples firstly showed that the leaves of cultivated A. argyi were 67.04 % larger and 24.28 % thicker than the wild A. argyi . Then, the integration of High-performance liquid chromatography method (HPLC) analysis with chemometrics demonstrated that cultivated A. argyi contained 39.59 % higher average levels of six key flavonoids and 16.98 % greater average contents of six phenolic acids compared to wild A. argyi . Furthermore, the Griess method assessment revealed that the inhibition of NO production in cultivated A. argyi was 15 % stronger by that in wild A. argyi at 10 and 20 μg/mL, confirming better anti-inflammatory efficacy of cultivated A. argyi . Meanwhile, the results of untargeted metabolomics analysis revealed nine differential volatile components. Cultivated A. argyi had 31.40 % lower oil yield but held advantages in the average contents of borneol and camphor. Importantly, the anti-bacterial activity of cultivated A. argyi is as good as the wild A. argyi . Hence, multidimensional evaluation based on phenotypic traits, chemometrics analysis, and pharmacodynamic activity demonstrated ...