Morning Administration is More Effective than Evening Administration of 0.01% Atropine Eye Drops Combined with Orthokeratology for Myopia Control

作者：Shuting Xiong, Xuewei Li, Yuchang Lu, Mengyao Zhang, Yan Li, Kai Wang · 发表于：Indian Journal of Ophthalmology · 年份：2025 · DOI：10.4103/ijo.ijo_3107_24 · 被引用次数：3 · 研究领域：Ophthalmology and Visual Impairment Studies、Retinopathy of Prematurity Studies、Corneal surgery and disorders

OBJECTIVE: To assess the varying myopia control outcomes between morning (QM) and evening (QN) application of 0.01% atropine drops in conjunction with orthokeratology (ortho-K) therapy in myopic children. METHODS: A total of 163 right eyes of myopic children were included, receiving either morning or evening 0.01% atropine combined with ortho-K, with 78 in the QM group. Age, gender, spherical equivalent refraction, axial length, e-value, average K-reading (Ave-K), and pupil diameter (PD) were all documented as baseline characteristics. Follow-up assessments at 1-, 3-, 6-, 9-, and 12-month visits were centered on alterations in treatment zone diameter (TZD), decentration, PD, and axial elongation. Parental refraction and children's behavioral factors, such as daily near-work time, outdoor activity time, reading and writing posture, and sweets consumption, were gathered through a questionnaire. RESULTS: At baseline, there were no significant differences in ocular characteristics between the two groups. After one month, the QM group exhibited a significantly larger PD compared to the QN group (4.09 ± 0.67 mm vs. 3.84 ± 0.76 mm, P = 0.03), while measurements for TZD and decentration showed no significant variance. Over the course of 1 year, the QM group demonstrated significantly less axial elongation than the QN group (0.13 ± 0.19 mm vs. 0.21 ± 0.16 mm, P < 0.05). Parental refraction and behavioral factors were similar between the groups, except for a lower consumption of sweets...