Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization

作者：Shuang-Yan Xiao, Kairong Su, Hongliang Gao, Chenyang Qiao, Sumei Sha, Xin Liu, Haitao Shi · 发表于：Mediators of Inflammation · 年份：2025 · DOI：10.1155/mi/1675577 · 被引用次数：4 · 研究领域：Inflammatory Bowel Disease、Liver Disease Diagnosis and Treatment、Microscopic Colitis

Background: Beyond intestinal inflammation, inflammatory bowel disease (IBD) is associated with many extraintestinal manifestations, particularly arthritis. However, systematic evidence regarding causal relationships between IBD and clinically prevalent arthritis subtypes remains limited. Methods: We conducted bidirectional two‐sample Mendelian randomization (MR) analyses to assess causal associations between IBD (Crohn’s disease [CD], ulcerative colitis [UC]) and seven arthritis subtypes: rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), osteoarthritis (OA), reactive arthritis (ReA), gout and pyogenic arthritis (PA). A two‐step MR (TSMR) analyses was subsequently performed to evaluate potential mediators across four domains: metabolites of gut microbiota, serum biochemical indicators, inflammatory/immune factors, and nutritional/metabolic indicators in IBD‐AS/PsA/ReA pathways. Results: MR analysis revealed that IBD increased the risk of AS (OR = 1.21, 95% CI: 1.11–1.32, P IVW < 0.001), PsA (OR = 1.18, 95% CI: 1.05–1.33, P IVW = 0.007), and ReA (OR = 1.11, 95% CI: 1.04–1.18, P IVW = 0.003). Subgroup analyses revealed CD increased the risk of AS (OR = 1.16, 95% CI: 1.07–1.27, P IVW < 0.001) and UC increased the risk of ReA (OR = 1.14, 95% CI: 1.04–1.24, P IVW = 0.005). The first step of the mediation MR showed that IBD was associated with increased butyrate levels, decreased serotonin levels, increased C‐reactive protein (CRP), increased ...