Para -(3-phenylpropiolamido)phenyl (PPAP) glycosides: Harnessing ipso -cyclization–driven glycosylation for strategic flexibility

作者：Meifang Yang, Yi-Yong Qiu, Yan Tan, Li Song, Xi Xiang, Yitian Zhao, Xing Zheng, Xing Zheng, Xiangwei Zheng, Xiangwei Zheng, Wei-Liang Gu, Guo‐Qiang Lin, Houchao Tao · 发表于：Science Advances · 年份：2025 · DOI：10.1126/sciadv.ady4274 · 被引用次数：5 · 研究领域：Carbohydrate Chemistry and Synthesis、Glycosylation and Glycoproteins Research、Legume Nitrogen Fixing Symbiosis

We herein report para -(3-phenylpropiolamido)phenyl (PPAP) glycosides as a novel class of glycosyl donors with distinct advantages for carbohydrate synthesis. These donors, featured by an intrinsically stable phenolic linkage, undergo glycosylation via a unique ipso -cyclization–mediated activation. Activated with N -iodosuccinimide (NIS)/trimethylsilyl trifluoromethanesulfonate (TMSOTf), PPAP donors support both O- and N-glycosylation across a broad range of substrates. Guided by density functional theory calculations, their design allows straightforward synthesis through a simple amide coupling reaction, facilitating diverse latent-active transformations and broadening their strategic utility. Furthermore, the distinct reactivity profile of PPAP donors—marked by a clear gap relative to other known donors and orthogonality to many standard activation methods—makes them well suited for modular, one-pot glycosylation strategies. Their ease of synthesis, robust performance in glycosylation, and compatibility with diverse assembly approaches collectively establish PPAP glycosides as powerful tools for the efficient construction of complex carbohydrates.