Noninvasive quantification of renal venous oxygenation with field‐insensitive T2 preparation and fast acquisition

作者：Qingyu Xu, Dengrong Jiang, Yi‐Cheng Hsu, Yi Zhang, Qin Qin, Hanzhang Lu, Dan Wu, Zixuan Lin · 发表于：Magnetic Resonance in Medicine · 年份：2025 · DOI：10.1002/mrm.70010 · 被引用次数：2 · 研究领域：Advanced MRI Techniques and Applications、MRI in cancer diagnosis、Atomic and Subatomic Physics Research

Abstract Purpose The development of a reliable MRI technique to quantify renal oxygen extraction fraction and metabolism can help in the evaluation of tissue hypoxia in kidney diseases. This study aims to develop a field inhomogeneity–insensitive and motion‐robust method for noninvasive renal oxygenation quantification. Methods A new sequence using adiabatic T 2 preparation (B 1 ‐insensitive‐rotation‐n) with Fourier transform–based velocity‐selective saturation and echo‐planar imaging readout was proposed, referred to as TRUFIFA (T 2 relaxation under field‐insensitive preparation and fast acquisition). We first demonstrated a robust T 2 quantification at different B 0 and B 1 offsets through simulation and phantom studies. Then, the sequence parameters were optimized in vivo with considerations of signal‐to‐noise ratio and contrast‐to‐noise ratio. The performance of the new sequence was shown using the comparison between B 1 ‐insensitive‐rotation‐n and MLEV T 2 preparation. Finally, the test–retest reproducibility of the new method was examined. Results Simulation and phantom studies demonstrated a robust T 2 quantification at different B 0 and B 1 offsets. Optimized free‐breathing TRUFIFA yielded an averaged Y v of 87.5 ± 2.6%, the feasibility of which in vivo was further shown by a positive correlation between venous T 2 and blood flow ( R 2 = 0.33). An excellent reproducibility was found with a coefficient of variation of intrasession (T 2 : 1.79 ± 0.88%, Y v : 0.88 ± 0.48...