Clusterin Regulates the Mechanisms of Neuroinflammation and Neuronal Circuit Impairment in Alzheimer’s Disease

作者：Yihang Yu, Chunjian Wang, Binbin Wang, Xuelin Wang, Qing Zhao, Yan Yan, Xiaoyun Liu · 发表于：International Journal of Molecular Sciences · 年份：2025 · DOI：10.3390/ijms26157271 · 被引用次数：7 · 研究领域：Clusterin in disease pathology、Alzheimer's disease research and treatments、Mitochondrial Function and Pathology

Alzheimer's disease (AD) is a neurodegenerative disease with a multifaceted pathogenesis, which remains elusive, seriously affecting the quality of life of elderly patients and placing a heavy burden on affected individuals, their families, and society. As third-party synapses in brain networks, astrocytes play an important role in maintaining the normal function of neural networks, which contribute to the abnormal function of networks in AD. In recent years, numerous studies have shown that clusterin, a protein expressed by astrocytes, can participate in the progression of AD. Clusterin plays a significant role in many pathological processes of AD, such as lipid metabolism, AD pathological features, the imbalance in neural circuit excitatory inhibition, and neuroinflammation. Therefore, delving deeper into the association between clusterin and AD will help us to understand the mechanisms of disease better and provide a theoretical basis for early diagnosis and the development of treatment strategies for AD.