Survival Outcomes in Young Nonsmoking–Nondrinking Individuals With Oral Cavity Squamous Cell Carcinoma

作者：Ryan T. Judd, Shruthi Sethuraman, Fahad Rind, Songzhu Zhao, Sarah C. Nyirjesy, Taylor Freeman, Enver Özer, Amit Agrawal, Kyle K. VanKoevering, Ricardo L. Carrau, James W. Rocco, Matthew Old, Lauren E. Miller, Stephen Y. Kang, Nolan B. Seim, Catherine T. Haring · 发表于：Head & Neck · 年份：2025 · DOI：10.1002/hed.28260 · 被引用次数：2 · 研究领域：Head and Neck Cancer Studies、Oral Health Pathology and Treatment、Oral health in cancer treatment

OBJECTIVE: To determine the impact of age and presence of traditional risk factors (smoking and drinking) on survival outcomes in a large cohort of patients with oral cavity squamous cell carcinoma (OCSCC). METHODS: This was a single-center, retrospective review from 2012 to 2019. Patients were divided by age (≤ 40 vs. > 40 years old) and whether they had significant tobacco and/or alcohol use history. Univariate and multivariate analyses were conducted to compare overall and disease-specific survival between the four groups. RESULTS: There were 630 patients, and median follow-up was 52.5 months. Young, nonsmoker-nondrinker (NSND) patients (N = 17) were more likely to be women with higher BMI, fewer medical comorbidities, primary tumors located on the oral tongue, and lower depth of invasion compared to older smoker-drinker (SD) counterparts. Young patients were more likely to receive adjuvant chemoradiation compared to those > 40 years old (38% vs. 18%, p = 0.007). Age/smoking-drinking history was not significantly associated with disease-free survival or overall survival. On multivariate analysis, the following variables were associated with worse disease-free survival: higher N stage (N1 vs. N0 HR 2.46 [95% CI 1.46-4.17], p < 0.001; N2 vs. N0 HR 3.55 [2.25-5.59], p < 0.001; N3 vs. N0 HR 2.94 [1.76-4.91], p < 0.001) and diagnosis of hypothyroidism (HR 2.25 [1.56-3.24], p < 0.001). On multivariate analysis, the following were associated with worse overall survival: lower BMI...