BAP1 Tumor Predisposition Syndrome

作者：Rossana N. Lazcano Segura, Mai P. Hoang · 发表于：Advances in Anatomic Pathology · 年份：2025 · DOI：10.1097/pap.0000000000000507 · 被引用次数：4 · 研究领域：Ocular Oncology and Treatments、Polyomavirus and related diseases、Cutaneous Melanoma Detection and Management

BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome is due to germline mutation of BAP1, a tumor suppressor gene. Patients with this syndrome has an increased susceptibility to the development of uveal melanomas, cutaneous melanomas, cutaneous atypical melanocytic lesions, mesotheliomas, clear cell renal cell carcinoma, and other tumors. These syndromic tumors exhibit an aggressive growth and earlier onset in comparison to sporadic tumors. In this review we outline the history, epidemiology, and genetics of this syndrome. The clinical presentation and histopathology of commonly developed tumors in syndromic patients, namely uveal melanomas, cutaneous atypical melanocytic lesions, mesotheliomas, and clear cell renal cell carcinoma are discussed.