Temporal Muscle Thickness as a New Biomarker: Its Association With Alzheimer Pathology and Cognitive Impairment in Chinese Adults

作者：Yunxia Zhu, Yingying Ke, Chenxi Ren, Jiehua Zhu, Zhen Zhang, Liang Cui, Yuehua Li, Fang Xie, Qihao Guo · 发表于：Journal of Cachexia Sarcopenia and Muscle · 年份：2025 · DOI：10.1002/jcsm.70030 · 被引用次数：7 · 研究领域：Nutrition and Health in Aging、Dementia and Cognitive Impairment Research、Dysphagia Assessment and Management

ABSTRACT Background The association between skeletal muscle mass loss and cognitive decline remains unclear. Temporal muscle thickness (TMT) has been validated as an easily obtainable surrogate marker for muscle mass loss in neurological patients. This study was aimed at exploring whether a decline in TMT correlates with Alzheimer's disease ( AD )–related cognitive impairment and its underlying mechanisms. Methods This study was a cross‐sectional substudy of the Chinese preclinical AD study, which included data from 801 participants. TMT was measured using cranial magnetic resonance imaging. Appendicular skeletal muscle index (ASMI) was estimated using an anthropometric equation as a control. Cognitive function was assessed using a battery of standardised neuropsychological tests, and participants were categorised into three groups based on clinical diagnosis: normal cognition (NC), mild cognitive impairment (MCI) and AD . Functional performance was evaluated using the Functional Activities Questionnaire. Of the 801 participants, 733 underwent 18 F‐florbetapir PET scans to assess cerebral amyloid‐beta (Aβ) deposition. Additionally, 165 Aβ‐PET‐positive participants were randomly selected for further evaluation of cerebral tau burden using 18 F‐MK6240 PET. Results Significant differences in TMT measurements were observed by age and sex, with thinner TMT found in females and older adults. TMT was significantly associated with ASMI, handgrip strength and mobility. Regarding cogni...